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Ta-Yuan Chang Selected Research

Sterol O-Acyltransferase

2/2022Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture.
12/2020Correction: Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
3/2016Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
7/2015Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
8/2013Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.
3/2006Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
3/2006Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.
3/2002Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency.
1/2002Mutant acyl-coenzyme A:cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active.

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Ta-Yuan Chang Research Topics

Disease

22Prostatic Neoplasms (Prostate Cancer)
01/2019 - 11/2009
17Neoplasms (Cancer)
02/2022 - 02/2006
14Atherosclerosis
02/2022 - 01/2002
9Alzheimer Disease (Alzheimer's Disease)
02/2022 - 07/2009
6Hypertension (High Blood Pressure)
05/2014 - 01/2009
5Inflammation (Inflammations)
01/2021 - 08/2013
5Neurodegenerative Diseases (Neurodegenerative Disease)
09/2019 - 03/2004
4Margins of Excision
07/2013 - 06/2010
3Hepatocellular Carcinoma (Hepatoma)
12/2020 - 03/2006
3Colorectal Neoplasms (Colorectal Cancer)
09/2013 - 01/2013
3Lymphatic Metastasis
07/2013 - 09/2010
2Neuroinflammatory Diseases
01/2021 - 12/2017
2Atherosclerotic Plaque (Atheroma)
01/2021 - 11/2003
2Hearing Loss (Hearing Impairment)
03/2020 - 04/2011
2Neuroblastoma
09/2018 - 07/2015
2Cardiovascular Diseases (Cardiovascular Disease)
01/2018 - 07/2015
2Disease Progression
09/2015 - 04/2013
2Neoplasm Metastasis (Metastasis)
01/2013 - 01/2010
2Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
06/2005 - 05/2003
1Dementia (Dementias)
01/2021
1Dyslipidemias (Dyslipidemia)
01/2021
1Cognitive Dysfunction
01/2021
1Fatigue
06/2020
1Lethargy
06/2020
1Nasopharyngeal Carcinoma
01/2020
1Myocardial Infarction
11/2019
1Tinnitus
02/2018
1Amyloid Plaque
12/2017
1Adenocarcinoma of Lung
01/2017
1Melanoma (Melanoma, Malignant)
03/2016
1Xanthomatosis (Xanthoma)
03/2016
1Alopecia (Baldness)
03/2016
1Skin Diseases (Skin Disease)
03/2016
1Leukocytosis (Pleocytosis)
03/2016
1Dry Eye Syndromes (Dry Eye Syndrome)
03/2016
1Disease Susceptibility (Diathesis)
04/2014
17 Hereditary Prostate Cancer
07/2013
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
01/2013

Drug/Important Bio-Agent (IBA)

12CholesterolIBA
01/2021 - 01/2002
11Biomarkers (Surrogate Marker)IBA
01/2019 - 03/2006
9Sterol O-AcyltransferaseIBA
02/2022 - 01/2002
7AndrogensIBA
11/2016 - 02/2011
5Apolipoproteins E (ApoE)IBA
01/2021 - 09/2013
5Proteins (Proteins, Gene)FDA Link
09/2018 - 07/2009
5EnzymesIBA
11/2016 - 03/2002
5Prostate-Specific Antigen (Semenogelase)IBA
07/2013 - 11/2009
4LipidsIBA
01/2021 - 11/2003
4Amyloid (Amyloid Fibrils)IBA
12/2017 - 04/2010
4Cholesterol Esters (Cholesteryl Esters)IBA
03/2016 - 03/2006
4Pharmaceutical PreparationsIBA
03/2016 - 01/2006
3Acyl Coenzyme A (Acyl CoA)IBA
07/2015 - 01/2002
3Transcription Factors (Transcription Factor)IBA
01/2015 - 11/2013
3ORALIT (ORS)IBA
05/2014 - 02/2011
2Particulate MatterIBA
11/2019 - 09/2019
2SootIBA
09/2019 - 09/2018
2Vehicle Emissions (Emissions, Vehicle)IBA
09/2019 - 09/2018
2Small Interfering RNA (siRNA)IBA
01/2018 - 09/2017
2Air Pollutants (Pollutants, Air)IBA
01/2018 - 07/2015
2Calcitriol Receptors (Calcitriol Receptor)IBA
09/2017 - 04/2013
2MicroRNAs (MicroRNA)IBA
12/2014 - 02/2011
2Carcinoembryonic AntigenIBA
09/2013 - 01/2013
1Protein Isoforms (Isoforms)IBA
01/2021
1Apolipoprotein E4IBA
01/2021
1Carbon DioxideIBA
06/2020
1AlbuminsIBA
03/2020
1CreatinineIBA
03/2020
1Benzo(a)pyreneIBA
11/2019
1Environmental Pollutants (Pollutants, Environmental)IBA
11/2019
1Adrenal Cortex Hormones (Corticosteroids)IBA
09/2019
1Caspase 3 (Caspase-3)IBA
09/2019
1Cell Adhesion MoleculesIBA
01/2019
1GlycosyltransferasesIBA
01/2018
1Peptides (Polypeptides)IBA
12/2017
1Vitamin DFDA LinkGeneric
09/2017
1Messenger RNA (mRNA)IBA
09/2017
1Zinc OxideFDA Link
01/2017
1AluminumIBA
01/2017
1ErbB Receptors (EGF Receptor)IBA
01/2017
1NucleotidesIBA
11/2016
1Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA
11/2016
1Folic Acid (Vitamin M)FDA LinkGeneric
11/2016
1Complementary DNA (cDNA)IBA
11/2016
1avasimibeIBA
03/2016
1Presenilin-1IBA
07/2015
1OxysterolsIBA
12/2013
1NF-kappa B (NF-kB)IBA
11/2013
1Interleukin-10 (Interleukin 10)IBA
09/2013
1CytokinesIBA
09/2013
1Viral ProteinsIBA
08/2013
1Insulin (Novolin)FDA Link
07/2013
1methyl 4-azidophenylacetimidate (APAI)IBA
04/2013
1Estrogens (Estrogen)FDA Link
01/2013
1Gonadal Steroid Hormones (Sex Hormones)IBA
01/2013
1Matrix Metalloproteinases (MMPs)IBA
01/2013
1Peptide Hydrolases (Proteases)FDA Link
01/2013

Therapy/Procedure

13Prostatectomy (Retropubic Prostatectomy)
01/2019 - 11/2009
10Therapeutics
01/2021 - 02/2011
1Transcranial Direct Current Stimulation
02/2018
1Immunotherapy
03/2016
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
09/2013